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 Head & Neck Institute
Head & Neck Cancer
Skull base Surgery
Facial Plastic & Cosmetic
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Cleft & Craniofacial Surgery

                    Ongoing Research Projects

Advances in translational research are paramount for the progress of clinical medicine, with patients having complex, and seemingly insurmountable problems providing a constant stimulus and direction for new avenues of exploration. A major hurdle in the implementation of such a program is the traditional lack of interaction between physicians and scientists. Recognizing this limitation, the head and neck translational research program is organized as an integral part of the clinical service. The primary mission of the program is to facilitate the translation of the developments in basic science research into clinical practice. It is anticipated that this approach will have a positive impact on the prevention, early diagnosis, treatment and ultimately, the cure and quality of life, of the patients suffering from head and neck cancer.

The major focus of our research program is in head and neck cancer early detection and prevention and tissue engineering. We have been successful in securing several competitive national and international research grants worth over one crore.
Funding Agency Project
1. National Institute of Health(NIH) Phase II randomized clinical trail of Sulindac in oral premalignant lesions. The project will attempt to establish the effectiveness of Sulindac as a potential of an international consortium in oral cancer prevention research between AIMS hospital and Memorial Sloan-Kettering Cancer Institute, New York.
3.Department of Biotechnology: Govt. of India  Phase II Chemoprevention trial of Curcumin in oral leukoplakia. This clinical trial will attempt to determine the effectiveness of Curcumin a derivative of Turmeric to treat oral precancer lesion- leukoplakia.
4. Kerala State Science, Technologyand Environment Research Council Infrastructure development grant. This grant is to equip a core research laboratory for head and neck oncology to facilitate translational research. Lymphoscintigraphy
5. Kerala State Science, Technology and Environment Research Council: Lymphocintigraphy for evaluation of nodal metastasis in Head and neck cancer. This project is to determine the feasibility of lymphoscintigraphy as a minimally invasive tool to detect sub-clinical lymph node metastasis.
6. Council of Scientific and Industrial Research, Govt. of India Gene expression profiling of head and neck squamous cell carcinoma by cDNA microarray. This project which is carried out in collaboration with Center for Cellular and Molecular Biology, Hydrebad; will attempt to develop a custom head and neck cancer gene-chip for characterization of the tumor at the molecular level.
7. Head and Neck Research Fund Validation of transcriptomes of Cancer associated genes in saliva of patients with oral Cancer The goal of this project is to identify cancer signature molecules in saliva, which may be used for early detection of cancer
8. Belcher Pharmaceuticals Study to evaluate the efficacy and safety of Muco 5232 a concentrated chewable gel wafer in reducing the severity of oral mucositis included by radiation with or without Chemotheraphy
9 Head and Neck Research Fund Speech out come after treatment of tongue cancer: comparison between different treatment methods. This project is to determine functional outcome of different methods of treating tongue cancer.
10. Department of Science and Technology, Govt. of India: Evaluation of oral self-examination in early detection of oral cancer In this rural community based research we plan to determine the feasibility of mouth self-examination for early detection of oral cancer.
11. Head and Neck Research Fund Elongation factor (eIF4) as a marker for sub microscopic metastasis in cervical lymph nodes This project involved development of a novel marker to identify sub-microscopic metastasis in cervical lymph nodes
12. wockhardt pharma Phase II study of antibiotic efficacy in complicated skin and soft tissue infections.
13. Head and Neck Research Fund: Study on prevalence of hypothyroidism in treated head and neck cancer patients and the effect of intervention on Quality of life.
14. Head and Neck Research Fund Pattern of spread of tumours of the gingivo-buccal sulcus. This is a histopathological study to evaluate pattern of spread of cancer of gingivo-buccal sulcus.
15. Head and Neck Research Fund Indigenous hydroxyapatite implants for chin and malar augmentation. This is a ongoing collaborative project with SCT center for research, Trivandrum
16. GSK pharmaceuticals Phase III randomize clinical trial of post-operative anti-EGFr tyrosine kinase inhibitor in high-risk head and neck cancer patients.
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