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CASE HISTORIES 2004 
Cancer Survivors Meet - 2004 Report

It was a celebration of new life. Overcoming fears, it was a celebration of beginning new lives when they came together and shared their experiences...


18 December, 2004 -The Amrita Cancer Institute conducted the Cancer Survivors Meet - 2004 on the 18th of December. The meet was led by Dr. T. K Padmanabhan, Dr. D. K. Vijaykumar,
Dr. Moni Abraham Kuriakose, and Dr. M. Dinesh of the Cancer Institute.

Acclaimed cine artist, Mr. Suresh Gopi, known for his compassion in societal challenges, inaugurated the function accompanied by Sampooja Swami Poornamritanandapuri, who blessed those in attendance with his holy presence and message. There was also a group music programme, "Madhura Smrithi" conducted by music director Mr. A. Ramachandran and his disciples, followed by variety entertainment by the Medical College students.

It was a first-of-its-kind opportunity to share the emotional bonds and supports for individuals who have recovered from cancer, and also for those who have been newly diagnosed. It was a heartfelt moment where those who have lived with, through and beyond the experience of having cancer were able to communicate the message of hope and help others who are still struggling to face their destiny.

Those attending listened to very honest and personal discussions of the fears, concerns and issues faced by each of the cancer survivors. They described the impact that cancer has had on their lives and their loved ones; their outlooks on the future and life in general; as well as the support and comfort that they have received in lessening the impact of these fears.

Sophie Jose, who was a breast cancer patient, in thanking all the doctors of Amrita Institute of Medical Sciences for giving her a life of new hopes and colors, said:


"It was such a shock when I came to know that I was having cancer. But I didn't give up hope; I took the steps to take care of myself. I had the extra caring and tremendous support from the doctors of AIMS. I wanted to live, and that's why I am living still now. Just to keep the faith and keep hope, and not let anybody take your hope away."

In the words of Rajesh, who is coming out of fears of throat cancer:

"I really felt shattered when I realized I was having cancer. My life was just to begin and the shadow of this disease made it utterly colorless. But slowly I began to examine myself from the inside out. The support of family and friends, prayer and the realization that my disease was deeper on the inside than the outside, all combined to strengthen my spirit and belief. I decided to go to Amrita Institute, which I have heard is the best among the cancer research institutes that offers hope and support for patients and their families. While undergoing the treatment, I began to feel better about myself. Now I remain free of cancer, and my disease taught me life's most important lesson that diseases are what makes someone wise; and what makes you realize how precious and valuable life really is."

One could sense the hard times he went through, and feel his strong will to face this challenge.

Then there was Mr. Sugathan, who had casinoma larnyx. He had been suffering major voice problems due to a growth in his vocal chord. He had undergone a radiation treatment, which was not the complete cure. The doctors at AIMS decided to do another surgery as he had voice related problems even after the radiation. The doctors removed his voice box, then did a speech valve surgery that gave him a new life. Now he is out of the danger of cancer and he is able to speak, too.

"I have got a new life, new breath, and a new voice. I am obliged to the AIMS Cancer Institute and doctors, who appeared before my destiny as a helping hand from God".

The Cancer Institute of Amrita Institute of Medical Sciences is dedicated to provide the highest quality of cancer care with compassion, in a modern, serene and respectful environment, with a wide range of experts in all disciplines related to cancer.

Head & Neck Institute Gives Yan Zhen a New Face
Yan Zhen before her surgeries at AIMS
A team from the Head and Neck Institute led by Dr. Moni Abraham Kuriakose and Dr. Subramanya Iyer performed four surgeries. They filled the hollow of her face, outlined her eyebrow and attached a fibre to the corner of her mouth to make her smile symmetrical. The highlight of the procedure was the reconstruction of the eye, complete with new upper and lower eyelids and eyelashes. The man behind Yan's new pair of eyes was Dr. Jijo Paul. "We had to redo the creation of eye-socket procedure a couple of times to get back to a normal shape," said Dr. Mony Abraham Kuriakose.
Dr. Sherry Peter, Dr. Mohit Sharma and Dr. Sasidharan were also part of the medical team from the Head and Neck Institute. During her six months stay in Cochin, AIMS provided Ellen and her mother with lodging facilities. Ellen is now free of tumour as well as the stigma associated with facial disfigurement. Yan Zhen, who once aspired to be a model, hopes to get her former job in a hotel. She should; the winner that she is - against the odds.
Yan Zhen after her surgeries at AIMS

Complex Open Heart Surgery on Two Day-Old Baby

 

July, 2004 -In what could be one of the youngest children to undergo complex open heart surgery in India, a one day old baby was referred to AIMS on 8th of July, 2004 from a local hospital for evaluation of suspected, complex congenital heart disease.

The baby was diagnosed by an emergency echocardiogram to have an obstructed infracardiac total anomalous venous connection. This called for emergency open heart surgery for the survival of the baby.

The Division of Pediatric and Congenital Heart Surgery successfully carried out the open heart surgery on the 2nd day of life of this baby who weighed 3kgs at birth. The surgical team was led by Dr. Suresh G. Rao, Chief Paediatric and Congenital Heart Surgeon. Other members included Dr. K. Shivaprakasha, Consultant Paediatric & CH Surgeon, and Drs. Sajan Koshy, Girish Warrier and Baiju S. Dharan.

The child had an uneventful post operative recovery and was discharged on 26th July, 2004.

Another Milestone for AIMS in Newborn Heart Surgery

 

July, 2004 -The Paediatric CVTS Division of the Department of Cardiovascular and Thoracic Surgery, has added another feather to its cap by crossing the milestone of performing more than 100 ‘Arterial Switch’ open heart surgeries on newborns having ‘Transposition of Great Arteries’ (TGA), with a 90% success rate.

Surgical correction of complex heart defects in the newborn age group is an undertaking needing extraordinary surgical skill and teamwork. TGA is essentially a complex heart defect where the origin of the vessels to the lungs and body are reversed, leaving blue blood circulating in the body with red (pure) blood going back to the lungs instead of the body. This circulation is incompatible with life after birth, and the newborn baby needs a procedure termed ‘Balloon Atrial Septostomy’ (BAS) immediately after birth. To achieve best long term results and correct the connections between the respective ventricles and blood vessels, an Arterial Switch Operation needs to be performed before 3 weeks of age, failing which the ventricle connected to the lungs will start to thin out.

This open heart surgery corrects the ventricle and vessel connection and also transfers the delicate coronary arteries to their normal vessel of origin. In addition it also allows correction of associated defects such as a ‘hole in the heart’ which is commonly found.
As the heart defect is totally corrected, the baby is expected to have a normal life thereafter, and the 30 year worldwide experience currently available appears very satisfying.

This complex open heart surgery in a newborn needs coordination, skill and excellence in postoperative care of the highest degree from Neonatologists, Paediatric Cardiologists, Cardiac Anaesthesiologists, Paediatric Cardiac Surgeons, Perfusionists, and Physiotherapists, with high calibre paediatric cardiac nursing care in the post operative period.

In a short span of 6 years AIMS has emerged as one of the four major centres in India doing this type of surgery successfully in newborns in large numbers. The other centres are located outside Kerala in New Delhi, Chennai and Bangalore. Internationally referred newborn babies to AIMS for arterial switch surgery from neighbouring countries like Maldives, and Middle east have also benefited from this experience.

The surgeries were carried out by Dr. Suresh G. Rao, Chief Paediatric Cardiac Surgeon AIMS,
and Dr. K. Shivaprakasha, Consultant Paediatric Cardiac Surgeon, assisted by cardiac surgeons, Drs. Sajan Koshy, Girish Warrier and Baiju Dharan. The initial stabilization by balloon atrial septostomy was done by Dr. R. Krishnakumar, Chief Paediatric Cardiologist and his team. Dr. Suresh G. Nair, Chief Cardiac Anaesthesiologist, and Drs. Suresh Chengode, Jiju John and Abraham Cherian were the Cardiac Anaesthesiologists involved in the anaesthetic care of these newborn babies.

Kerala's First Liver Transplant
RAMDAS AFTER LIVER TRANSPLANTATION
July, 2004 -The Digestive Diseases Department at AIMS performed the first liver transplantation and multi-organ harvesting in Kerala. The surgery was carried out on the late night of 27th June and proceeded well into the early morning of the 28th.

The donor was a 62 year old retired engineer who had suffered head injuries and consequent brain death in a road traffic accident. His family was magnanimous enough to offer his liver and kidneys for organ donation, despite it being the occasion of their greatest grief and distress.

The patient, Mr. Ramdas, a 33 year old male was admitted in a critical condition with end stage liver disease due to cirrhosis resulting from viral hepatitis and was on a steady downhill course. His relatives were informed that without a liver transplant, his chance of survival was low. When the donor family had agreed to donate the liver, Ramdas and family were eager for the liver transplant.

The AIMS transplantation team worked in close co-ordination with SORT (Society for Organ Retrieval and Transplantation - a network of hospitals in Kochi to share organs from willing donors).

The organ harvesting and liver transplantation was carried out by a large surgical team headed by Dr. Sudhindran of the Vascular and Transplant Surgery Unit and comprised the entire GI surgical team. The donor surgery was completed in around three and a half hours whilst the recipient surgery was finished in 7 hours.

BAD LIVER OF RAMDAS
Ramdas fortunately made a dramatic improvement and is currently doing well in the postoperative recovery ward. The initial phase of his treatment is over and his body seems to have accepted the new liver without any attempt at rejection.

The kidneys of the donor were harvested simultaneously as well. One kidney was transplanted to a patient in AIMS itself by a team headed by Dr. Sanjay Bhat of the Urology Department. The other kidney was transferred to PVS hospital Kochi for transplantation to another matching recipient through the endeavors of SORT. This inter-hospital transfer of organs took place for the first time in Kerala and will hopefully be a commencement to many more such accomplishments and thereby bring hope to large number of similar unfortunate sufferers.

Long-Term Outlook - The GI and Transplantation team at AIMS had all the infrastructure and trained manpower for liver transplantation for the last three years or so. There were more than 10 patients waiting for a new liver. The major hurdle in achieving this landmark was the lack of availability of organs. In the India the concept of brain death and organ donation is yet to take root. Many a times we find that a consent that is given by the younger generation is withdrawn at the last moment by one of the older relatives. The only way to overcome the paucity of donor organs that we face now will be to promote and educate the populace about brain death in general and multiple organ donation in particular.
Nuclear Medicine Utilises Gamma Probe

Tongue cancer patient receiving radioactive injection prior to surgery
February, 2004 - The Nuclear Medicine Department has recently been equipped with a sophisticated new, hand held, cordless, miniature gamma camera instrument called a Gamma Probe. Very few nuclear medicine centres in India are equipped with this instrument, which is manufactured in Germany. The Gamma Probe is particularly useful during cancer surgeries by onco surgeons and Head and Neck surgeons, and endocrine surgeons for breast, head and neck, thyroid, vulval and penile cancers, melanoma and also in parathyroid tumours.
The advantages of using this instrument during these surgeries are:
  • accurate localisation of tumour/lymph nodes
  • minimising skin incisions
  • intra-operative time
  • reducing blood loss
  • ensuring complete removal of tumour
  • minimising in-hospital stay
  • increasing patient compliance and comfort.

Sentinel node being marked on the skin surface using Gamma Camera
Basic Principle of the Technique
Lymph node being localized using Gamma Probe during surgery
Just prior to surgery, lympho scintigraphy imaging is performed where minute amounts of radioactive colloids are injected to the patient and the lymphatic drainage pattern is studied using a Gamma Camera. Subsequently the first draining lymph node is identified called the sentinel lymph node, which will most likely be the first to be affected by metastasis. A negative sentinel node makes it highly unlikely that other nodes are involved in that region.
During surgery using the Gamma Probe, this sentinel node is identified, excised and sent for biopsy (frozen section). The test confirms either the presence or absence of cancer in the sample and is performed before completion of the surgery enabling the surgeon to decide whether to do more extensive, mutilating lymph node removal. This represents a significant advantage as a minimally invasive procedure, considering that after surgery, about 70% of patients are found to be free from metastatic disease. The success rate of radioguidance in localizing the sentinel lymph nodes in cancer surgery is about 94 - 97%.

Radioactivity in the excised lymph node being confirmed after surgery
For localizing parathyroid tumours, the principle for gamma probe surgeries is different. A Technetium Sestamibi scan is conducted to confirm the presence of the tumour, looking for ectopic parathyroid adenomas. Pre-operatively the skin overlying this neck tumour is marked so that surgeon incises just above the tumour site, minimizing the size of incisions. Successful complete excision of tumour is ensured once again with a gamma probe .It also screens the entire neck for presence of other unidentified tumours by way of imaging.

This Gamma probe radio guided surgeries are extensively used in US and European hospitals with proven efficacy. The Department of Nuclear Medicine offers this new, exclusive and immensely beneficial facility to our patients in association with onco surgeons, head and neck surgeons and endocrine surgeons at AIMS.

The Amrita Journal is part of the Amrita Institute of Medical Science website